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Phytosphingosine and Ceramide

Phytosphingosine is considered a precursor to Ceramides, which are the dominant fat that fills in the cracks between skin cells.Phytosphingosine is a natural, skin-identical active ingredient for personal care products.Ceramides are lipids (fats) that are found naturally in high concentrations in the uppermost layers of skin. Ceramides helps reinforce your skin's barrier and increase hydration—giving you plumper, smoother, firmer-feeling skin with fewer visible lines and wrinkles, as well as fewer signs of sensitivity.

  • Product Name Phytosphingosine and Ceramide
  • Product Process Fermentation
  • Functions Anti-aging,Regulate cell growth variation,.moisturizing
  • Applications Cosmetics, Medical and Food industries

Phytosphingosine is a natural, skin-identical active ingredient for personal care products. It is naturally present in the skin and effectively reduces the signs of acne, inhibits the growth of micro-organisms on the skin, reduces redness and inflamed skin and is active at very low concentrations. Phytosphingosine and Phytosphingosine Hydrochloride are especially suitable for O/W creams and lotions of the segments eye care products, irritated skin products, skin suffering from acne, blemished skin and atopic skin.

Ceramides are produced from Phytosphingosine.Ceramides are waxy lipid molecules (fatty acids), Ceramides are found in the outer layers of the skin and play a vital role ensuring there are the correct amount of lipids that are lost throughout the day after the skin is exposed to environmental aggressors.Ceramides are naturally occurring lipids in the human body. They are essential to the skin’s health as they form the skin’s barrier which protects it from damage, bacteria and water loss.

Ceramide,also named as N-acylsphingosine,Ceramide NP is a synthetic N-acylated sphingolipid consisting of Phytosphingosine having the D-erythro structure linked to normal saturated or unsaturated fatty acid.There are many different types from different suppliers,Ceramide NP,Ceramide III,Ceramide IIIB,Ceramide VI,Ceramide AP,Ceramide EOP and etc.

Ceramide NP is a skin-identical barrier lipid. It supports the renewal of the skin’s natural protective layer and form an effective barrier against moisture loss. It strengthens the barrier function, promotes skin comfort and is particularly suitable for long-term protection & support of sensitive & dry skin’s recovery. It improves long-term moisturization, repairs and protects damaged hair. It is produced using a patented biofermentation processes. Possible applications of Ceramide III include dry skin recover & care face cream, after shower body care, shampoos and clear leave in conditioners.

Ceramide NP/Ceramide IIIB is a Ceramide that reinforces the skins natural protective lipid barrier. Ceramide IIIB consists of a Phytosphingosine backbone acylated with oleic acid. Ceramide III B differs from Ceramide III in that it has one unsaturated bond in its fatty acid chain Ceramide III and Ceramide III B support the renewal of the skin’s natural protective layer and form an effective barrier against moisture loss. These human-skin-identical molecules are therefore particularly suitable for long term protection and repair of sensitive and dry skin. In hair care formulations Ceramide III and Ceramide IIIB are able to restore damaged hair and to protect hair against chemical and UV damage

Ceramide AP is a synthetic N-acylated sphingolipid consisting of Phytosphingosine having the D-erythro structure linked to an alpha-hydroxy saturated or unsaturated fatty acid.Ceramide AP acts as an anti-pollution-, hydrating- and mild peeling agent. It is a high purity Ceramide similar to those found in human skin and is produced by yeast fermentation process. It helps to strengthen skin barrier function and helps to retain moisture of the skin. It prevents the deposition and penetration of pollutants on skin. Ceramide AP functions as a mild AHA and allows healthy skin peeling. It can be used in skin care, make-up and other cosmetic products.

Ceramide EOP is a synthetic N-acylated sphingolipid consisting of Phytosphingosine having the D-erythro structure linked to an esterified omega-hydroxy saturated or unsaturated fatty acid This Nourishing Hand Cream is an emulsion, designed for dry and damaged skin.

 Phytosphingosine

Key Technical Paraments:

1.Phytosphingosine

Appearance

White or off white powder

Assay(HPLC-CAD)

90.0% min.

Purity(HPLC-CAD)

90.0% min.

Water

2.0% max.

Heavy Metals

20 ppm max.

Residue on Ignition

0.5% max.

Total Aerobic Bacteria

100 cfu/g max.

Yeast & Mold

10 cfu/g max.

2.Ceramide NP/Ceramide III

Appearance

White or off white powder

Assay(HPLC-UV)

95.0% min.(A+B+C+D)

Purity(HPLC UV)

A: 85.0% min.

A+B+C+D: 95.0% min.

Loss on Drying

2.0% max.

Heavy Metals

20 ppm max.

Residue on Ignition

0.5% max.

Melting Point

98℃~108℃

Total Aerobic Bacteria

100 cfu/g max.

Yeast & Mold

10 cfu/g max.

Residue Solvents

Methol: 3,000 ppm max.

Ethol: 5,000 ppm max.

Ethylis Oleas: 3,000 ppm max.

3.Ceramide NP/Ceramide IIIB

Appearance

White or off white powder

Assay(HPLC-UV)

95.0% min.

Purity(HPLC UV)

95.0% min.

Loss on Drying

2.0% max.

Heavy Metals

20 ppm max.

Residue on Ignition

0.5% max.

Total Aerobic Bacteria

100 cfu/g max.

Yeast & Mold

10 cfu/g max.

Residue Solvents

Methol: 3,000 ppm max.

Ethol: 5,000 ppm max.

Ethylis Oleas: 3,000 ppm max.

Ethyl Acetate: 3,000 ppm max.

Butyl Acetate: 3,000 ppm max.

4.Ceramide AP

Appearance

White or off white powder or particles

Identifications

Cosistent with the reference solution

Assay (on Dried basis)

95.0% min.

Purity(HPLC-UV)

95.0% min.

Loss on Drying

2.0% max.

Residue on Ignition

0.5% max.

Heavy Metals

20 ppm max.

Total Aerobic Bacteria

100 cfu/g max.

Yeast & Mold

10 cfu/g max.

5.Ceramide EOP

Appearance

White or off white powder

Identifications

IR

Odor

Mild Characteristic Odor

Assay

90.0% min.

Di,multi sub.Phytosphingosine

7.0% max.

Free Phytosphingosine

2.0% max.

Loss on Drying

2.0% max.

Heavy Metals

20 ppm max.

Arsenic

2 ppm max.

 

Functions:

•Phytosphingosine/Ceramide in maintaining the skin barrier function plays a very important role.
•Phytosphingosine/Ceramide can obviously enhance the adhesion between keratinocytes, improve dry skin, reduce skin desquamation.
•Phytosphingosine/Ceramide maintains skin moisture.
•Phytosphingosine/Ceramide has Anti-aging function.
•Phytosphingosine/Ceramide can regulate cell growth variation.
•Phytosphingosine/Ceramide is cytotoxic regulator in the cell.

Applications:

Phytosphingosine/Ceramide can be used in Cosmetic, medical and Food products.



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