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Polyquaternium-1

Short Description:

Polyquaternium-1 is a very safe preservative, which shows very low acute toxicity in rats.Polyquaternium-1 is slightly toxic orally (LD50> 4.47 ml/l at 40% active in rats). Polyquaternium-1 is not irritating to skin at 40%. The product is not a skin sensitizer and is non-mutagenic.


  • Product Name: Polyquaternium-1  
  • Synonyms: Polidronium Chloride,PQ-1
  • CAS NO.: 75345-27-6  
  • Molecuar Formula: C22H48Cl3N3O6
  • Product Detail

    Product Tags

    Polyquaternium-1 is a detergent-type preservative derived from BAK,also named as Polidronium Chloride,PQ-1.Polyquaternium-1 is formulated in the mid of 1980s by Alcon as a preservative for contact lens storage solutions.Nowadays,it is being increasingly used as a presverative in ophthalmic drops for glaucoma, artificial tear solutions and top cosmetic formuations.

    Polyquaternium-1 is a cationic polymer prepared by the controlled polymerization of dimethylamine and bis-dichlorobutene, end capped with tris-b-Hydroxyethylamine.

    Key Technical Parameters:

    (1) 95~100% Solid:

    Appearance Amber to dark brown solid
    Odor Without Stimulation
    Water solubility Full Soluble
    Free Amine 5.0%
    pH 6.0~9.0
    Chloride <30%
    Internal standard content ≥95%
    Total Number of Aerobic Microbial Count(TAMC)  cfu/g <10³ cfu/g
    Total Yeasts and Molds Count(TYMC) cfu/g <10² cfu/g

    (2) 40% liquid :

    Appearance Light yellow liquid
    Odor Without Stimulation
    Molecular Weight 30,000~40,000
    Solid Content ≥33%
    Chloride ≤10%
    Free Amin ≤2.0%
    pH 6~9
    Water Solubility 100% Soluble
    Total Aerobic Microbial Count(TAMC) <1000cfu/g
    Total Yeasts and Molds Count(TYMC) <100 cfg/g

    Applications:

    Polyquaternium-1is an antimicrobial preservative, with higher antimicrobial effects and lower ocular irritation.used as bactericide in eye drops,soft lenses product and other ophalmic care products formulation.In skin care formulations,it can help to avoid or reduce the allergy and infection possibility.

    *Preservative

    *Antimicrobial for use in products targeting mucus membrane or other sensitive tissue

    *Antimicrobial for use in dermatological applications and trans-dermal patch pharmaceuticals

    *Antimicrobial for use as surface protection for medical devices

    Toxicity:

    Polyquaternium-1 is a very safe preservative, which shows very low acute toxicity in rats.Polyquaternium-1 is slightly toxic orally (LD50> 4.47 ml/l at 40% active in rats). Polyquaternium-1  is not irritating to skin at 40%. The product is not a skin sensitizer and is non-mutagenic.


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