Povidone
Povidone ke homopolymer ea 1-vinyl-2-pyrrolidone (Polyvinylpyrrolidone), e qhibiliha ka bolokolohi ka metsing, ka ethanol (96%), methanol le lintho tse ling tse qhibilihisang manyolo, e qhibilihang habobebe ka har'a acetone. Ke polima e kopantsoeng, e fanoang ka phofo e tšoeu kapa e bosoeu e bosoeu kapa li-flakes, ho tloha ho tlase ho ea holimo e phahameng le e tlase ho ea ho boima bo phahameng ba limolek'hule, bo khetholloang ke boleng ba K, bo nang le hygroscopisty e ntle haholo, boqapi ba lifilimi, likhomaretsi, botsitso ba lik'hemik'hale le litlhaku tse sireletsehileng tsa chefo.
Mekhoa ea Bohlokoa ea Bohlale:
|
Sehlahisoa |
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| Ponahalo | Bosoeu kapa bosoeu bo bosehla, phofo e nyane kapa li-flakes | ||||
| Ho qhibiliha | E qhibiliha ka bolokolohi ka metsing ka ethanol (96%) le methanol, e qhibilihang hanyane ka hanyane ho acetone | ||||
| Ponahalo ea Tharollo | E hlakile ebile ha e na mebala e matla ho feta tharollo ea litšupiso B6, BY6 kapa R6 | ||||
| Boitsebiso | Ponahalo ea IR e fumanoeng e tsamaellana le e bolokiloeng le Povidone CRS. | ||||
| Ho thehoa buluoa bo bosehla ba lamunu | |||||
| Ho hlahisoa 'mala o pinki oa CA | |||||
| Ho hlahisoa 'mala o mofubelu oa DA | |||||
| Sesebelisoa se qhibiliha | |||||
| pH (5% ka metsing) | 3.0 ~ 5.0 | 3.0 ~ 5.0 | 3.0 ~ 5.0 | 3.0 ~ 5.0 | 4.0 ~ 7.0 |
| K Bohlokoa | 12.75 ~ 17.25 | 15.30 ~ 18.36 | 22.50 ~ 27.00 | 27.00-32.40 | EA-81.00 ~ 97.20 |
| Li-aldehyde | 500 ppm, max. | 500 ppm, max. | 500 ppm, max. | 500 ppm, max. | 500 ppm, max. |
| Peroxide | 400 ppm, max. | 400 ppm, max. | 400 ppm, max. | 400 ppm, max. | 400 ppm, max. |
| Mofuta oa Acid | 0.5%, max. | 0.5%, max. | 0.5%, max. | 0.5%, max. | 0.5%, max. |
| Hydrazine | 1 ppm, max. | 1 ppm, max. | 1 ppm, max. | 1 ppm, max. | 1 ppm, max. |
| Ho se hloeke A | 10 ppm, max. | 10 ppm, max. | 10 ppm, max. | 10 ppm, max. | 10 ppm, max. |
| Ho se hloeke B | Boholo ba 3.0% | Boholo ba 3.0% | Boholo ba 3.0% | Boholo ba 3.0% | Boholo ba 3.0% |
| Lisebelisoa tse boima | 10 ppm, max. | 10 ppm, max. | 10 ppm, max. | 10 ppm, max. | 10 ppm, max. |
| Metsi | Boholo ba 5.0% | Boholo ba 5.0% | Boholo ba 5.0% | Boholo ba 5.0% | Boholo ba 5.0% |
| Sulphated Ash | 0,1%, max. | 0,1%, max. | 0,1%, max. | 0,1%, max. | 0,1%, max. |
| Litaba tsa Naetrojene | 11.5 ~ 12.8% | 11.5 ~ 12.8% | 11.5 ~ 12.8% | 11.5 ~ 12.8% | 11.5 ~ 12.8% |
Likopo:
Povidone e na le thepa e ntle haholo e tlamang, e etsang lifilimi, e qhalanang le e sarolohang. Ke e 'ngoe ea lihlahisoa tsa bohlokoahali lefatšeng ka bophara bakeng sa indasteri ea meriana, eng kapa eng bakeng sa lihlahisoa tsa tlhokomelo ea bophelo ba batho kapa lihlahisoa tsa tlhokomelo ea bophelo ba liphoofolo. Binder bakeng sa litafole, capsule.It ke a loketse bakeng sa granulation metsi le omileng le compression e tobileng ka tafoleng, ho ntlafatsa phatsa compressibility le ka li ekeletsoa metsoako phofo ka omileng kapa qhalwa ke metsi, joala. 2) Liaparo tsa tsoekere le lifilimi, 3) Solubility Ts'oaetso ea lithethefatsi tse qhibilihang hampe, 4) Enhancer ea bioavailability bakeng sa metsoako e sebetsang ea lithethefatsi, 5) Ho iketsetsa lihlahisoa tsa lera.
