IPovidone
IPovidone i-homopolymer ye-1-vinyl-2-pyrrolidone (IPolyvinylpyrrolidone), inyibilika ngokukhululekileyo emanzini, kwi-ethanol (96%), kwi-methanol, kunye nezinye izinyibilikisi ze-organic, inyibilikiswa kancinci kwi-acetone. Yipolymer yegroscopic, ebonelelwa ngomgubo omhlophe okanye ocoliweyo omhlophe okanye iiflakes, ukusukela ezantsi ukuya kwi-viscosity ephezulu kunye nezantsi ukuya kubunzima obuphezulu beemolekyuli, ezibonakaliswa liXabiso le-K, ngobuchwephesha obugqwesileyo, ukuyilwa kwefilimu, ukunamathela, uzinzo lweekhemikhali kunye neempawu ezinobungozi zetyhefu.
Iiparamitha zoBuchule eziPhambili:
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Imveliso |
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| Inkangeleko | Mhlophe okanye tyheli-mhlophe, umgubo ongumgubo okanye iiflakes | ||||
| Ukunyibilika | Ukunyibilika ngokukhululekileyo emanzini kwi-ethanol (96%) nakwi-methanol, inyibilika kancinci kwi-acetone | ||||
| Inkangeleko ye Isisombululo | Ngokucacileyo kwaye ayinombala onamandla ngakumbi kunesisombululo sesalathiso B6, BY6 okanye R6 | ||||
| Ukuchonga | I-spectrum ye-IR efunyenweyo iyahambelana naleyo ifunyenwe ne IPovidone IiCR. | ||||
| B. Kwenziwa i-orenji etyheli ngombala | |||||
| Umbala opinki we-CA uveliswa | |||||
| Umbala obomvu we-DA uyaveliswa | |||||
| Ewe into inyibilika | |||||
| pH (5% emanzini) | 3.0 ~ 5.0 | 3.0 ~ 5.0 | 3.0 ~ 5.0 | 3.0 ~ 5.0 | 4.0 ~ 7.0 |
| K Ixabiso | 12.75 ~ 17.25 | 15.30 ~ 18.36 | 22.50 ~ 27.00 | 27.00-32.40 | I-81.00 ~ 97.20 |
| IAldehyde | 500 ppm ubuninzi. | 500 ppm ubuninzi. | 500 ppm ubuninzi. | 500 ppm ubuninzi. | 500 ppm ubuninzi. |
| Iperoxides | 400 ppm ubuninzi. | 400 ppm ubuninzi. | 400 ppm ubuninzi. | 400 ppm ubuninzi. | 400 ppm ubuninzi. |
| Ifomic Acid | 0.5% ubuninzi. | 0.5% ubuninzi. | 0.5% ubuninzi. | 0.5% ubuninzi. | 0.5% ubuninzi. |
| IHydrazine | 1 ppm ubuninzi. | 1 ppm ubuninzi. | 1 ppm ubuninzi. | 1 ppm ubuninzi. | 1 ppm ubuninzi. |
| Ukucoceka A | 10 ppm ubuninzi. | 10 ppm ubuninzi. | 10 ppm ubuninzi. | 10 ppm ubuninzi. | 10 ppm ubuninzi. |
| Ukucoceka B | Ubungakanani be3.0% | Ubungakanani be3.0% | Ubungakanani be3.0% | Ubungakanani be3.0% | Ubungakanani be3.0% |
| Amatye anzima | 10 ppm ubuninzi. | 10 ppm ubuninzi. | 10 ppm ubuninzi. | 10 ppm ubuninzi. | 10 ppm ubuninzi. |
| Amanzi | 5.0% ubuninzi. | 5.0% ubuninzi. | 5.0% ubuninzi. | 5.0% ubuninzi. | 5.0% ubuninzi. |
| Sulphated Ash | 0.1% ubuninzi. | 0.1% ubuninzi. | 0.1% ubuninzi. | 0.1% ubuninzi. | 0.1% ubuninzi. |
| Umxholo weNitrogen | 11.5 ~ 12.8% | 11.5 ~ 12.8% | 11.5 ~ 12.8% | 11.5 ~ 12.8% | 11.5 ~ 12.8% |
Izicelo:
I-Povidone inokubopha okubalaseleyo, ukwenza ifilimu, ukusasaza kunye nokwenza iipropathi ukuba zezinye zezona zinto zibaluleke kakhulu kwihlabathi liphela kushishino lwamayeza, nokuba yeyiphi na kwimveliso yokhathalelo lwempilo yabantu okanye iimveliso zonyango lwezilwanyana. I-Binder yeetafile, i-capsule.Yilungele i-granulation emanzi neyomileyo kunye nokunyanzeliswa ngokuthe ngqo kwitheyibhile, ukuphucula ukunyanzeliswa kweengqungquthela kwaye kungongezwa kwimixube ye powder eyomileyo okanye echithwe ngamanzi, utywala. 2) Iingubo zeShukela kunye neefilimu, 3) Impembelelo yamachiza anyibilikayo angalunganga, i-4) i-Bioavailability Enhancer yezixhobo ezisebenzayo zeziyobisi, i-5) Ukwenza iipore kwimveliso yeembrane.
