I-Kojic Acid Dipalmitate iguquliwe kokuphuma kwe-Kojic Acid okungagcini nje ngokunqoba ukungazinzi kokukhanya, ukushisa nama-ion ensimbi, kodwa futhi igcina impahla enhle kakhulu yokuvimbela umsebenzi we-tyrosinase esikhumbeni somuntu futhi ivimbele ukwakheka kwe-melanin.Isebenza kakhulu kune-Kojic Acid.I-Kojic Dipalmitate ingaveza imiphumela emihle kakhulu ngisho nasekuqiniseni isikhumba, ukulwa namabala obudala, izimpawu zokukhulelwa, amabala kanye nokuphazamiseka kwesikhumba okuvamile kobuso nomzimba.Ngokungafani ne-Kojic Acid, evame ukudala izinkinga zokuzinza komkhiqizo ezifana nokushintsha kombala, i-Kojic Acid Dipalmitate inikeza ukuzinza okuhle kakhulu komkhiqizo ngaphandle kwezinkinga zokungaqini kombala.

1. Ukukhanya Kwesikhumba: I-Kojic Acid Dipalmitate inikeza imiphumela esebenza ngempumelelo yokukhanyisa isikhumba.Uma iqhathaniswa ne-Kojic Acid, i-Kojic Dipalmitate ithuthukisa ngokuphawulekayo imiphumela evimbelayo emsebenzini we-tyrosinase, ovimbela ukwakheka kwe-melanin.Njengomenzeli ocwenga uwoyela wesikhumba, kulula ukumuncwa isikhumba.

2. Ukuzinza Kokukhanya Nokushisa:I-Kojic Acid Dipalmitate ilula futhi nokushisa kuzinzile, Kodwa i-Kojic Acid ivamise uku-oxidize ngokuhamba kwesikhathi.

3. Ukuzinza kwe-pH: I-Kojic Acid Dipalmitate izinzile ngaphakathi kwebanga le-pH elibanzi lika-4-9, elihlinzeka ngokuguquguquka kubadidiyeli.

4. Ukuqina Kombala: I-Kojic Acid Dipalmitate ayishintshi ibe nsundu noma ibe phuzi ngokuhamba kwesikhathi, ngoba i-Kojic Acid Dipalmitate izinzile ku-pH, ukukhanya, ukushisa kanye ne-oxidation, futhi ayihlanganisi nama-ion ensimbi, aholela ekuzinzeni kombala.

I-Kojic Acid Dipalmitate (KAD)iwumkhiqizo osuselwe ku-Kojic Acid, yaziwa nangokuthi i-Kojic Dipalmitate.I-Kojic Acid Dipalmitate iyi-ejenti ethandwayo eyenza isikhumba sibe mhlophe.Ngaphambi kokwethula i-Kojic Acid Dipalmitate.I-Kojic Acid iyabiliswa futhi ihlanzwe nge-glucose noma i-sucrose ngaphansi kwesenzo se-koji.Indlela yayo yokwenza mhlophe iwukuvimbela kokubili umsebenzi we-tyrosinase nomsebenzi we-N-DHICA oxidaSe.Futhi ingavimba i-dihydroxyindole polymerization.I-Kojic Acid iyi-ejenti emhlophe eyodwa engavamile evimbela ama-enzyme amaningi ngesikhathi esisodwa.Kukhona ukhilimu we-Kojic Acid, insipho ye-Kojic Acid emakethe.Kodwa-ke, ukusetshenziswa kwe-Kojic Acid esikhumbeni kancane kancane kuthathelwa indawo okuphuma kuyo.

Ngenxa ye-Kojic Acid ayizinzile ekukhanyeni, ekushiseni nase-ion yensimbi.Ayimuncwa kalula isikhumba.Ngakho kwavela okuphuma ku-Kojic Acid.Abacwaningi basungule inani lokuphuma kwe-Kojic Acid ukuze bathuthukise ukusebenza kwe-Kojic Acid.Okuphuma kokunye akugcini nje ngokuba nendlela yokwenza mhlophe efana ne-Kojic Acid, kodwa futhi kunokusebenza okungcono kune-Kojic Acid.I-ejenti emhlophe ye-Kojic Acid edume kakhulu okwamanje emakethe yi-Kojic Acid Dipalmitate (KAD).Iwukuphuma kwe-diesterified kwe-Kojic Acid.Kutholwe ukuthi inhlanganisela ye-KAD kanye ne-glucosamine derivatives izokwandisa umphumela wokwenza isikhumba sibe mhlophe.

I-Kojic Acid yaziwa njenge-5- hydroxyl -2- hydroxymethyl -1 kanye ne-4- piranone.I-acidic organic compound ebuthakathaka eyenziwe ukuvutshelwa kwama-microorganisms.Fine tramperic acid iyinaliti emhlophe noma ephuzi njengekristalu;Incibilika kalula emanzini, utshwala ne-acetone, incibilika kancane ku-ether, i-ethyl acetate, i-chloroform ne-pyridine, engancibiliki ku-benzene;ifomula yayo yamangqamuzana ithi C₆H₆O₄,Molecularweight142.1,Iphuzu lokuncibilika153～156℃.

I-Kojic Acid isetshenziswa emkhakheni wezimonyo.Esikhumbeni somuntu, i-tyrosine ihlanganiswa yi-oxidation eyinkimbinkimbi kanye ne-polymerization yama-radicals mahhala oksijini ngaphansi kwe-catalysis ye-tyrosinase, futhi ekugcineni i-melanin iyahlanganiswa.I-Kojic Acid ingavimbela ukuhlanganiswa kwe-tyrosinase, ngakho-ke ingavimbela ngokuqinile ukwakheka kwe-melanin yesikhumba, futhi iphephile futhi ayinabungozi, futhi ngeke ikhiqize i-leukoplakia, ngakho-ke i-Kojic yengezwe emanzini okwenza, imaski, i-emulsion. , ukhilimu wesikhumba, futhi ingakwazi ukwelapha ngempumelelo ama-freckles, amabala obudala, umbala, i-acne nezinye izimonyo ezimhlophe.20ug/ml.Izinhlobonhlobo ze-tyrosinase zingavinjelwa ukuhlushwa kwe-Kojic Acid 70 kuya ku-80% yobungqabavu kunconywa izimonyo. , yengeza u-0.2 kuya ku-1%.I-Kojic Acid iwumkhiqizo wokukhiqiza i-maltol ne-ethyl maltol.Ekwezemithi, i-Kojic Acid ayinawo umthelela we-mutagenic kumaseli e-eukaryotic, futhi ingaqeda ama-radicals mahhala angaphakathi, ithuthukise amandla eseli elimhlophe, futhi ibe yinzuzo empilweni yomzimba womuntu.Ngakho-ke, i-Kojic Acid isivele isetshenziswa njengempahla eluhlaza ye-cephalosporins, futhi umkhiqizo osuphelile usetshenziselwa ukwelapha izifo ezinjengobuhlungu bekhanda kanye nezinyo, kanye nemiphumela yokudambisa ubuhlungu kanye ne-anti-inflammatory iyishumi Hlukanisa okuhle.Ensimini yezolimo, ingasetshenziswa ukukhiqiza izibulala-zinambuzane eziphilayo.Umanyolo omncane we-bio (uketshezi olubomvu olujulile), owenziwe ngo-0.5 kuya ku-1% we-Kojic Acids, ufakwa ezinhlangeni nasemifino, kungakhathaliseki ukuthi ugxilile ophansi njengomanyolo we-foliar noma i-ejenti ekhulayo yokukhula ekufakweni kwezimpande.I-Kojic Acid ingakwazi futhi ingasetshenziswa njenge-reagent yokuhlaziya i-iron, i-film speckle inhibitor, njll.

Izinzuzo zokusebenzisa imikhiqizo equkethe i-Kojic Acid zingabandakanya lokhu okulandelayo:

• Umphumela Wokuguga:Imikhiqizo equkethe i-Kojic Acid ingase yenze isikhumba sibe lula, esingathuthukisa ukubukeka kwamabala obudala nokulimala kwelanga.Ukuncishiswa kwamabala amnyama kungaba nomthelela wokulwa nokuguga.
• Ukwelapha i-Melasma:I-Kojic Acid ingase ibe usizo ekwehliseni i-melasma, okuba mnyama kwesikhumba ngenxa yokukhulelwa.
• Nciphisa Ukubukeka Kwezibazi:I-Kojic Acid ingase futhi yehlise ukuguga kwezibazi.Nakuba i-asidi ingathuthukisi ukujiya kwezicubu ezibaziyo, ingase inciphise umbala omnyama ohambisana nezinhlobo ezithile zezibazi.Ukukhanyisa isibazi kungase kusenze singabonakali.
• Izinzuzo ze-Antifungal:I-Kojic Acid kucatshangwa ukuthi inezinzuzo ezithile ze-antifungal.Kungase kube usizo ekuvimbeleni nasekwelapheni izifo ezithile zokukhunta, njengezifo zonyawo lomsubathi kanye nemvubelo.
• Imithelela ye-Antibacterial:I-Kojic Acid ingase futhi inikeze izinzuzo zokulwa namagciwane.Kungase kusize ukunciphisa amathuba okuthuthukisa izinhlobo ezivamile zezifo zesikhumba ezibangelwa amagciwane.