Trifluoroacetyl Tripeptide-2

Short Description:

Trifluoroacetyl Tripeptide-2 is also called Progeline. It is a biomimetic peptide for a protein inhibitor called progerin. Progerin appears when there is a mutation in our genes due to aging.Trifluoroacetyl Tripeptide-2 is a 3 amino acids peptide biomimetic of elafin that modulates progerin, a new senescence marker, for a complete remodelling effect and reduction of the appearance of wrinkles. 



  • Product Name: Trifluoroacetyl Tripeptide-2
  • Product Code: YNR-TT2
  • INCI Name: Progeline;Trifluoroacetyl Tripeptide 2
  • CAS No.: 64577-63-5
  • Synonyms: Progeline;N-(Trifluoroacetyl)valyltyrosylvaline;Tfa-Val-Tyr-Val-OH;N-(2,2,2-Trifluoroacetyl)-L-valyl-L-tyrosyl-L-valine
  • Molecular Weight: 475.46
  • Product Detail

    Why Choose YR Chemspec

    Product Tags

    Trifluoroacetyl Tripeptide-2(Trifluoroacetyltripeptide-2)/Progeline is an active tripeptide derived from elastase inhibitor. It can reduce the synthesis of premature aging protein, improve the skin relaxation, sagging and wrinkles caused by it, improve the skin firmness, elasticity and improve the facial contour. security information.

    Cosmetic Palmitoyl Tripeptide

    A peptide is a chain of amino acids connected by peptide bonds. Peptides are mainly involved in protein regulation, angiogenesis, cell proliferation, melanogenesis, cell migration and inflammation. In the past few decades, bioactive peptides have been widely used in the cosmetic industry. Peptides need to have low molecular weight (<500 Da), high stability and solubility to reduce the diffusion of peptides between epidermal layers. Over the years, the scientific community has developed small, stable synthetic peptide fragments that can activate collagen production and reduce facial wrinkles and pigmentation. Trifluoroacetyl Tripeptide-2 is a synthetic tripeptide designed as a matrix metalloproteinase and elastase inhibitor. In vitro studies were conducted to evaluate the effects of Trifluoroacetyl Tripeptide-2 on ECM protection, proteoglycan synthesis in cell-matrix interactions, and progerin synthesis in mature human normal fibroblasts. This protein has recently been identified As a common inducer of cellular senescence. The results show that Trifluoroacetyl Tripeptide-2 has a wider range of anti-aging properties. It can reduce the synthesis of presenilin, increase the production of proteoglycans and shrink collagen, so it can reduce wrinkles and increase tissue stiffness. In addition, its anti-wrinkle, anti-sagging and skin firming effects were evaluated in two in vitro split face studies. According to research, Trifluoroacetyl Tripeptide-2 has a gradual effect on wrinkles, firmness, elasticity and sagging.

    Key Technical Parameters



    Appearance                    White to off-white powder
    Identity by ESI-MS                      Theoretical MW:475.46
    Water (K.F.)

    Not more than 7.0%

    Purity (HPLC)

    Not less than 98.0%

    Trifluoroacetic acid content



    1. Trifluoroacetyl Tripeptide-2/Progeline reduces progerin synthesis, MMP and elastase inhibitor, increases syndecan, contracts collagen to reduce signs of aging including sagging and wrinkles.

    2. Trifluoroacetyl Tripeptide-2/Progeline to a young cell level to delay cell senescence.

    3. Trifluoroacetyl Tripeptide-2/Progeline boosts collagen production and inhibits degradation enzymes activity(collagenase,elastase,MMP-1,MMP-3,MMP-9).

    4. Trifluoroacetyl Tripeptide-2/Progeline able to help increase the production of collagen, reduce the look of wrinkles, and diminish the appearance of sagging.

    Peptide ProgelineApplication

    Trifluoroacetyl Tripeptide-2/Progeline /Peptide Progeline works by stimulating sirtuin production and activity to extend cell lifespan. When applied to the skin, it relaxes facial tension, which leads to the reduction in facial lines and wrinkles when used as directed.  will reduces facial tension and movement by literally paralyzing facial muscles. it can be used to make a variety of serums, creams, masks and gels.

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