Xanthohumol (XN) is a flavonoid. It is currently only found in hops. The content of Xanthohumol in hops is 0.1% to 1%. Xanthohumol is slightly soluble in water, and easily soluble in ethanol. It has a variety of pharmacological activities. It is widely used in medicine and health care industries. Meanwhile, Xanthohumol can inhibit melanin production induced by xanthine via inhibiting the expression of tyrosinase and related enzymes. Its elimination rate of oxygen free radicals in the body is several times higher than other antioxidants; its antioxidant activity is stronger than VE, 200 times stronger than resveratrol. It can effectively scavenge harmful free radicals in human body. Xanthohumol inhibits the activity of cyclooxygenase and lipoxygenase; it kills diseased bacteria, viruses and fungi, and alleviates skin acne problem. Therefore, Xanthohumol shows prospective application in the cosmetics market. Y&R develops 5% Xanthohumol that is cosmetic grade.